Atsbio.com Courses

Targeting Talk: Time Course

Immunofluorescence Atsbio.com

1 hours ago The figure below illustrates the time course of cell death very effectively. Internalization and cytotoxicity of SP-SAP in primary cultures of neonatal spinal cord neurons (11). Confocal image of neurons where the Substance P receptor; NK1R (SPR) immunofluorescence (A, C, D) appears red, areas of concentrated SPR immunofluorescence appear yellow.

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14q1 Atsbio.com

Course Atsbio.com

8 hours ago Targeting Talk: Time Course. How long does it take to see the cell death occurring from the use of targeted toxins using saporin? Is there a time course of hours or days? The figure below illustrates the time course of cell death very effectively. Internalization and cytotoxicity of SP-SAP in primary cultures of neonatal spinal cord neurons (11).

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Targeting Talk: Dose Ranging

Approach Atsbio.com

1 hours ago Start with a few animals and do dose-ranging as discussed in the previous question. The various modes of application are really too wide to discuss in any detail here, but I, a biochemist by training, always like the approach of thinking about what sort of concentration will be needed to have a cytotoxic effect.

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Targeting Trends Newsletter 01q4

Carlsbad Atsbio.com

(858) 642-1988

6 hours ago Is there a time course of hours or days? Order Online and receive 10% off your order of $100 or more PLUS free shipping! Read More. Product Search. Advanced Targeting Systems, Inc. c/o CytoLogistics 6352 Corte del Abeto, Ste B / Carlsbad, CA 92011 USA Monday-Thursday 6am-2pm PST Friday 8am – 4pm (858) 642-1988

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Abstracts From Society For Neuroscience (SFN) 2017

Abstracts Atsbio.com

8 hours ago Abstracts from Society for Neuroscience (SFN) 2017. 72.2 /KK24 Glutamate and adenosine, basal forebrain andu000bcortex: Cross-talk during prolonged wakefulness. A A Larin, S A Karpova, R W Mccarley, R Basheer, A V Kalinchuk. featuring IT-01 192-IgG …

Website: https://atsbio.com/sfn-2017/

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Targeting Talk: Product Questions

Cells Atsbio.com

1 hours ago The usual time-course for saporin toxins is that behavioral effects start appearing at four days and usually plateau at seven days. However, keep in mind that it takes some time for dead cells to be cleared out, so histology on the animal should wait until at least two weeks after administration.

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Abstracts From Society For Neuroscience (SFN) – New

Shipping! Atsbio.com

8 hours ago 51.22 SENSORY TRAINING IMPROVES THE ABILITY TO PROCESS STIMULI IN BARREL CORTEX AFTER BASAL FOREBRAIN LESION. 10% Off PLUS Free Shipping! 10% Off PLUS Free Shipping! Order Online and receive 10% off your order of $100 or more PLUS free

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2019 Scientific References

Cardiac Atsbio.com

Just Now Cardiac hypertrophy in mice submitted to a swimming protocol: influence of training volume and intensity on myocardial renin-angiotensin system. (2019) Soares DdS, et al. Am J Physiol Regul Integr Comp Physiol, 316 (6):R776-R782. Incubation at 4°C with anti-AT1R diluted in …

Website: https://atsbio.com/tt2019refs/

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Targeting Trends Newsletter 14q1

Information Atsbio.com

6 hours ago FDA Gives Green Light to Human Clinical Trials for Cancer Pain (continued on page 6) Contributed by Douglas A. Lappi, Ph.D., President/Chief Scientific Officer, Advanced Targeting Systems, San Diego, CAProduct information related to cover article: SP-SAP. Spring Brain Conference 25th Anniversary

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Abstracts From Society For Neuroscience (SFN) Chicago, IL

7432/R17 Atsbio.com

8 hours ago 743.2/R17 Dendritic atrophy following partial motoneuron depletion: Time course of recovery and protection with androgens and estrogens. K D Coons, F Munoz, M C Osborne, D R Sengelaub. featuring IT-14 CTB-SAP (Poster; Wednesday, Oct. 21, 9:00 am – 10:00 am)

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New Publications Using Saporin Conjugates

Differential Atsbio.com

6 hours ago Differential mechanisms are required for phrenic long-term facilitation over the course of motor neuron loss following CTB-SAP intrapleural injections. Borkowski LF, & Nichols NL. (2020). Exp Neurol, 334 113460. 2020/09/12. B rowse hundreds of scientific publications using saporin conjugates and …

Website: https://atsbio.com/ttopics-2020nov1/

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Recent Publications Using ATS Products

CTB-SAP Atsbio.com

843.843-843

4 hours ago Recent Publications using ATS Products. Borkowski LF, & Nichols NL. A2A and 5-HT Receptors are Differentially Required for Respiratory Plasticity Over the Course of Motor Neuron Loss in Intrapleurally CTB-SAP Treated Rats. (2019). FASEB J, 33 (1_supplement):843.843-843.843. IT-14: CTB-SAP Dose: Bilateral, intrapleural injections of: 1) CTB-SAP

Website: https://atsbio.com/ttopics-19dec5/

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SSPSAP Kit [KIT11] Atsbio.com

SSP-SAP Atsbio.com

4 hours ago SSP-SAP is a conjugation of saporin and SSP, the Sar 9, Met(O 2) 11 analog of Substance P. These two amino acid replacements are at two sites of digestion by tissue proteases (there is a third that is still in the analog, so it does eventually get degraded).

Website: https://atsbio.com/products/kit11/

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Abstracts From Society For Neuroscience (SFN) San Diego

Partial Atsbio.com

8 hours ago Abstracts from Society for Neuroscience (SFN) San Diego, CA • November 3-7, 2007. 56.11/S5 Protection from dendritic atrophy with testosterone following partial motoneuron depletion: dose-dependence in males and efficacy in females. 56.24/S18 Dendritic atrophy following partial motoneuron depletion: time course of recovery and protection with

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Cancer Pain Relief In Pet Dogs Has Direct Translation Into

Standard Atsbio.com

3 hours ago The standard treatment for dogs with late-stage bone cancer can include opioids, steroids, and palliative radiation. All of these treatments can have negative side effects. The owners of 70 dogs enrolled their pets in this study. Half the dogs received an injection of a neurotoxin, called substance P-saporin (SP-SAP), as well as standard care.

Website: https://atsbio.com/tt14q4-spsap1/

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Targeting Topics 07q2 Atsbio.com

Sensory Atsbio.com

1 hours ago Targeting Topics 07q2. Cholinergic modulation of sensory interference in rat primary somatosensory cortical neurons. Alenda A, Nunez A. Brain Res 1133 (1):158-167, 2007. One critical feature of cognition is the ability to focus on selected sensory inputs while ignoring irrelevant inputs. In this work the authors examine basal forebrain

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Cover Article: Carrageenan Evoked PAkt In Deep Dorsal

Neurons Atsbio.com

5 hours ago Contributed by L.S. Sorkin, J.-I. Choi, and F.J. Koehrn, Univ. California San Diego, La Jolla, CA. Paw inflammation with carrageenan elicits phosphorylation of Akt in spinal cord neurons with an unusual time course (Choi et al., 2010).Activation of Akt is seen first in neurons of the superficial dorsal horn and in α-motor neurons, followed by its appearance as much as 2 hrs after injection in

Website: https://atsbio.com/tt11q2-article1/

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SPCTA References

Sleep Atsbio.com

659 44-47

Just Now Cat #IT-39. Zielinski MR, & Gerashchenko D. Sleep-inducing effect of substance P-cholera toxin A subunit in mice. (2017). Neurosci Lett, 659 44-47. 09/01. Objective: To determine the effects of selectively activating SP-expressing brain cells on sleep regulation in mice. Summary: ICV administration of SP-CTA produces increased amounts of NREM sleep but induces sleep fragmentation.

Website: https://atsbio.com/references/refs-it39/

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Targeting Topics 16q2 Atsbio.com

Protein Atsbio.com

1 hours ago Neural Plast 2016:2769735, 2016. PMID: 26862439. TDP-43 (Transactive response DNA-binding protein) is a highly conserved nuclear protein that binds both DNA and RNA. It has been found in cytoplasmic protein aggregates of patients with conditions such as amyotrophic lateral sclerosis and …

Website: https://atsbio.com/tt16q2-refs/

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Cover Article: Selective Lesions Of Amygdala Intercalated

Likhtik Atsbio.com

5 hours ago Introduction by Douglas Lappi, Ph.D., President/CSO: This quarter’s Cover Article is from Ekaterina Likhtik who reprises her recently published work in Nature 454:642-645. In the News and Views, Sah and Westbrook comment that “Neuronal receptors in these circuits—such as those targeted with saporin in Likhtik and colleagues’ study—are likely to become targets for the development of

Website: https://atsbio.com/tt08q4-article1/

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Targeting Topics 15q2 Atsbio.com

Injections Atsbio.com

1 hours ago The authors investigated the relationship between preoperative Conditioned Pain Modulation (CPM) and the time course of recovery from surgery. CPM was evaluated using forepaw capsaicin injections into rats. During the study, lesioned rats received 5-μg intrathecal injections of anti-DBH-SAP (Cat.

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Targeting Topics Atsbio.com

Borkowski Atsbio.com

843.843-843

3 hours ago Borkowski LF, & Nichols NL. A2A and 5-HT Receptors are Differentially Required for Respiratory Plasticity Over the Course of Motor Neuron Loss in Intrapleurally CTB-SAP Treated Rats. (2019). FASEB J, 33 (1_supplement):843.843-843.843.

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Targeting Topics 11q1 Atsbio.com

Acquisition Atsbio.com

1 hours ago #IT-01) into the third ventricle after behavioral training. Lesioned animals had decreased protein and mRNA for both Arc and BDNF. Memory acquisition and recovery of acquisition were both affected. 10% Off PLUS Free Shipping! 10% Off PLUS Free Shipping! Order Online and receive 10% off your order of $100 or more PLUS free shipping! Read More.

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News Feed – Page 2

Borkowski Atsbio.com

843.843-843

5 hours ago Borkowski LF, & Nichols NL. A2A and 5-HT Receptors are Differentially Required for Respiratory Plasticity Over the Course of Motor Neuron Loss in Intrapleurally CTB-SAP Treated Rats. (2019). FASEB J, 33 (1_supplement):843.843-843.843.

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